VPS33A

Across TCGA cell cohorts, VPS33A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,410 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible VPS33A-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with VPS33A in more than 12 cancer types. Because this analysis shows association rather than direction, both VPS33A-to-partner and partner-to-VPS33A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by VPS33A-low versus VPS33A-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS33A→partner) and Y-score (partner→VPS33A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	rRNA 5'-end processing →	+0.102	+0.672	<.001	<.001	3	13
BLOOD_Lymphoma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.102	+0.672	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.132	+0.846	.002	<.001	3	13
PANCREAS	Translation reinitiation →	+0.095	+0.734	<.001	.001	3	12
STOMACH	Endosomal vesicle fusion →	+0.126	+0.771	<.001	.003	2	13
OVARY	DNA-templated transcription initiation →	+0.064	+0.827	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,410 associations by consensus.

rRNA 5'-end processing by VPS33A expression — BLOOD_Lymphoma

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