VPS33A

Across TCGA cell cohorts, VPS33A mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS33A-associated genes across cancer lineages are OR2L5, OR2L8, and RBP2. Each is linked with VPS33A in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS33A-to-partner and partner-to-VPS33A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L5 grouped by VPS33A-low versus VPS33A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS33A→partner) and Y-score (partner→VPS33A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L5 →	+0.012	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.020	+6.266	<.001	<.001	3	1
BLOOD_Leukemia	RBP2 →	+0.040	+4.037	.002	.004	3	1
BLOOD_Leukemia	DCLK3 →	+0.311	+3.769	<.001	.008	3	1
BLOOD_Leukemia	INSM2 →	+0.218	+3.769	<.001	.008	3	1
BLOOD_Leukemia	OR9A2 →	+0.041	+4.133	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR2L5 by VPS33A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →