VPS28

Across TCGA pan-cancer cohorts, VPS28 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS28 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS28 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS28 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where VPS28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.933	0.536	.002	20	view →
UCEC	DFS	Quartile	All	0.959	0.767	.008	16	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	10	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	3	view →
CCRCC	DFS	Tertile	III,IV	0.887	0.198	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS28–HNSC (DFS)

Open the HNSC breakdown →