VPS28

Across TCGA pan-cancer cohorts, VPS28 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of VPS28’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where VPS28 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS28 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LIHC, KIRC, and HNSC are the cancer types where VPS28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.671	<.001	9	view →
KIRC	Female	All	+0.512	<.001	9	view →
HNSC	All	IV	+0.508	.001	9	view →
COAD	All	IV	+0.864	<.001	8	view →
BRCA	All	III,IV	+0.731	<.001	6	view →
CHOL	Female	All	+2.219	<.001	5	view →
KICH	Female	All	−0.782	<.001	5	view →
STAD	Male	II,III,IV	+0.496	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

VPS28–LIHC

Open the LIHC breakdown →