VPS28

Across TCGA patient cohorts, VPS28 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS28-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK2, and MSH6. Each is linked with VPS28 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS28-to-partner and partner-to-VPS28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by VPS28-low versus VPS28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS28→partner) and Y-score (partner→VPS28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.143	-2.999	.036	.035	3	1
UCEC	JNK2 →	+0.257	+3.169	.018	.020	3	1
UCEC	MSH6 →	-0.777	-2.999	<.001	.035	3	1
UCEC	MSH2 →	-0.436	-2.990	<.001	.036	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.758	+3.169	.006	.020	1	1
UCEC	VHL →	-1.388	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FOXO3a_pS318_S321 by VPS28 expression — UCEC

Explore this box plot interactively →