VPS26B

Across TCGA pan-cancer cohorts, VPS26B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS26B data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VPS26B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS26B expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where VPS26B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.708	0.904	.006	12	view →
GBM	DFS	Quartile	All	0.578	0.240	.001	5	view →
LUAD	OS	Quartile	All	1.000	0.630	.015	5	view →
LSCC	DFS	Median	II,III,IV	0.558	0.807	.014	4	view →
HNSC	DFS	Median	IV	0.885	0.718	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS26B–CCRCC (DFS)

Open the CCRCC breakdown →