VPS26B

Across TCGA pan-cancer cohorts, VPS26B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of VPS26B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VPS26B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS26B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, LIHC, and LUAD are the cancer types where VPS26B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS26B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.512	<.001	10	view →
LIHC	Male	All	+0.719	<.001	8	view →
LUAD	All	All	+0.242	<.001	5	view →
KICH	All	All	−0.515	<.001	4	view →
LUSC	All	All	+0.262	.002	4	view →
CHOL	All	All	+0.715	<.001	2	view →
KIRP	All	IV	+0.642	<.001	2	view →
PRAD	All	All	+0.490	<.001	2	view →
STAD	All	II,III,IV	+0.450	.010	2	view →
THCA	Male	III,IV	−0.351	.016	2	view →
ESCA	Female	All	+0.810	.034	1	view →
COAD	Male	II,III,IV	+0.182	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

VPS26B–KIRC

Open the KIRC breakdown →