VPS18

Across TCGA patient cohorts, VPS18 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS18-associated genes across cancer lineages are Caspase-7-cleavedD198, Rictor_pT1135, and ATM. Each is linked with VPS18 in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS18-to-partner and partner-to-VPS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by VPS18-low versus VPS18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS18→partner) and Y-score (partner→VPS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.977	+2.824	.017	.034	3	3
UCEC	Rictor_pT1135 →	-0.093	-1.807	.013	.025	3	2
UCEC	ATM →	-0.676	-2.736	<.001	<.001	3	2
SKCM	PR →	-0.087	-2.987	.039	.035	3	2
COAD	Claudin-7 →	+0.899	+3.008	.009	.019	2	2
UCEC	eEF2 →	+0.396	+1.847	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by VPS18 expression — COAD

Explore this box plot interactively →