VPS18

Across TCGA pan-cancer cohorts, VPS18 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated VPS18 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VPS18 RNA is associated with better overall survival. In most high-consensus cancer types, elevated VPS18 expression acts as an unfavorable survival marker, although some lineages such as MESO and SARC show a favorable association.

MESO, COAD, and LUAD are the cancer types where VPS18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.499	0.285	.002	65	view →
COAD	DFS	Tertile	IV	0.276	0.621	<.001	63	view →
LUAD	DFS	Tertile	All	0.729	0.833	<.001	61	view →
SARC	OS	Tertile	All	0.835	0.605	<.001	39	view →
KIRC	DFS	Tertile	All	0.738	0.520	<.001	31	view →
UCEC	DFS	Tertile	III,IV	0.739	0.421	.002	24	view →
UCS	OS	Median	IV	0.276	0.749	.005	22	view →
SCLC	OS	Quartile	All	0.863	0.505	.004	21	view →
LUSC	OS	Median	III,IV	0.526	0.935	.006	19	view →
OV	OS	Quartile	All	0.261	0.369	.008	18	view →
DLBC	DFS	Median	All	1.000	0.635	.019	15	view →
HNSC	OS	Quartile	All	0.608	0.885	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

VPS18–MESO (OS)

Open the MESO breakdown →