VPS18

Across TCGA cell cohorts, VPS18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,910 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible VPS18-associated GO terms across cancer lineages are Endosomal vesicle fusion, Negative regulation of intracellular estrogen receptor signaling pathway, and Autophagosome-lysosome fusion. Each is linked with VPS18 in more than 19 cancer types. Because this analysis shows association rather than direction, both VPS18-to-partner and partner-to-VPS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal vesicle fusion grouped by VPS18-low versus VPS18-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS18→partner) and Y-score (partner→VPS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Endosomal vesicle fusion →	+0.122	+0.886	<.001	<.001	3	20
BONE	Negative regulation of intracellular estrogen receptor signaling pathway →	+0.159	+0.756	<.001	<.001	3	18
OESOPHAGUS	Autophagosome-lysosome fusion →	+0.134	+1.006	<.001	.002	3	18
STOMACH	Cytosolic transport →	+0.074	+0.979	.005	.002	3	16
LARGE_INTESTINE	Regulation of intracellular estrogen receptor signaling pathway →	+0.113	+1.182	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.055	+0.648	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,910 associations by consensus.

Endosomal vesicle fusion by VPS18 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →