VPS18

Across TCGA cell cohorts, VPS18 mutation is significantly associated with the RNA expression of many other genes, with 1,281 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS18-associated genes across cancer lineages are OR10K2, OR10T2, and C20orf85. Each is linked with VPS18 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS18-to-partner and partner-to-VPS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K2 grouped by VPS18-low versus VPS18-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS18→partner) and Y-score (partner→VPS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	2
BLOOD_Leukemia	OR10T2 →	+0.600	+3.106	<.001	.005	3	2
BLOOD_Leukemia	C20orf85 →	+0.030	+4.554	<.001	<.001	3	2
BLOOD_Leukemia	DNAH9 →	+0.931	+3.657	<.001	.006	3	2
LARGE_INTESTINE	FAM160A1 →	+1.156	+3.364	<.001	.002	3	2
LARGE_INTESTINE	BCDIN3D →	+0.555	+3.451	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,281 associations by consensus.

OR10K2 by VPS18 expression — BREAST

Explore this box plot interactively →