VPS13C

Across TCGA pan-cancer cohorts, VPS13C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS13C data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VPS13C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS13C expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where VPS13C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.542	0.855	.010	16	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.393	<.001	15	view →
LUAD	DFS	Median	All	0.739	0.519	.013	5	view →
PDAC	DFS	Tertile	III,IV	0.455	0.234	.036	5	view →
GBM	OS	Median	All	0.285	0.471	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS13C–LSCC (DFS)

Open the LSCC breakdown →