VPS13C

Across TCGA pan-cancer cohorts, VPS13C RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VPS13C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VPS13C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS13C is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

HNSC, LUSC, and LIHC are the cancer types where VPS13C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS13C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.802	<.001	9	view →
LUSC	Male	II,III,IV	−0.752	<.001	7	view →
LIHC	All	All	+0.467	<.001	6	view →
BRCA	Female	All	−0.387	<.001	6	view →
CHOL	All	All	+1.552	<.001	5	view →
STAD	Male	II,III,IV	+0.951	.006	4	view →
UCEC	All	All	−0.747	.003	2	view →
KICH	All	All	−0.594	.003	2	view →
LUAD	Female	II,III,IV	−0.574	.019	2	view →
THCA	All	All	−0.272	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

VPS13C–HNSC

Open the HNSC breakdown →