VPS13C

Across TCGA patient cohorts, VPS13C mutation is significantly associated with the RNA expression of many other genes, with 8,774 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS13C-associated genes across cancer lineages are NARF, CDC7, and NSD2. Each is linked with VPS13C in more than 5 cancer types. Because this analysis shows association rather than direction, both VPS13C-to-partner and partner-to-VPS13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NARF grouped by VPS13C-low versus VPS13C-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13C→partner) and Y-score (partner→VPS13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NARF →	+0.475	+2.714	.001	.002	3	6
COAD	CDC7 →	+0.669	+2.906	<.001	.001	3	6
UCEC	NSD2 →	+0.454	+1.446	<.001	<.001	3	5
UCEC	PSMD9 →	+0.342	+1.554	<.001	<.001	3	5
LUAD	RFC5 →	+0.471	+3.333	.003	.005	3	5
COAD	BCAS2 →	+0.346	+2.710	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,774 associations by consensus.

NARF by VPS13C expression — BLCA

Explore this box plot interactively →