VPS13C

Across TCGA cell cohorts, VPS13C mutation is significantly associated with the RNA expression of many other genes, with 434 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS13C-associated genes across cancer lineages are MEP1A, GYPB, and OR52B2. Each is linked with VPS13C in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS13C-to-partner and partner-to-VPS13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP1A grouped by VPS13C-low versus VPS13C-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13C→partner) and Y-score (partner→VPS13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MEP1A →	+0.007	+4.285	<.001	.003	3	2
KIDNEY	GYPB →	+0.114	+3.369	<.001	.003	3	2
LIVER	OR52B2 →	+0.022	+3.662	.002	.005	3	2
LARGE_INTESTINE	RPF1 →	+0.458	+1.572	.004	.001	3	2
LARGE_INTESTINE	PPP3CC →	+0.586	+3.546	.001	<.001	3	2
LARGE_INTESTINE	ZUP1 →	+0.430	+1.290	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 434 associations by consensus.

MEP1A by VPS13C expression — BLOOD_Myeloma

Explore this box plot interactively →