VPS13B

Across TCGA patient cohorts, VPS13B mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS13B-associated genes across cancer lineages are ASNS, Annexin_VII, and C-Raf. Each is linked with VPS13B in more than 4 cancer types. Because this analysis shows association rather than direction, both VPS13B-to-partner and partner-to-VPS13B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by VPS13B-low versus VPS13B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13B→partner) and Y-score (partner→VPS13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.491	+2.078	<.001	<.001	3	5
BLCA	Annexin_VII →	-0.120	-1.502	.018	.028	3	4
LUAD	C-Raf →	+0.126	+3.195	.014	.009	3	4
COAD	FASN →	+0.383	+1.178	.001	.043	3	4
COAD	PKC-a →	-0.223	-1.700	.011	.040	3	4
UCEC	4E-BP1 →	+0.284	+2.432	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

ASNS by VPS13B expression — COAD

Explore this box plot interactively →