VPS13B

Across TCGA pan-cancer cohorts, VPS13B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated VPS13B data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher VPS13B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS13B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

UVM, KIRC, and SCLC are the cancer types where VPS13B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.233	0.837	<.001	96	view →
KIRC	OS	Tertile	All	0.750	0.542	<.001	84	view →
SCLC	OS	Quartile	All	0.638	0.257	.002	39	view →
OV	OS	Quartile	All	0.252	0.409	.003	38	view →
UCEC	DFS	Tertile	All	0.560	0.676	.004	34	view →
THCA	OS	Median	All	0.982	0.997	.004	32	view →
LUSC	DFS	Quartile	III,IV	0.146	0.951	<.001	28	view →
ACC	DFS	Tertile	All	0.520	0.844	.001	22	view →
HNSC	DFS	Tertile	All	0.468	0.298	.003	17	view →
COAD	DFS	Median	III,IV	0.453	0.749	.008	16	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	12	view →
MESO	DFS	Quartile	All	0.306	0.528	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

VPS13B–UVM (DFS)

Open the UVM breakdown →