VPS13B

Across TCGA cell cohorts, VPS13B mutation is significantly associated with the RNA expression of many other genes, with 2,023 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS13B-associated genes across cancer lineages are MCF2L, CEACAM16, and NCR3. Each is linked with VPS13B in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS13B-to-partner and partner-to-VPS13B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCF2L grouped by VPS13B-low versus VPS13B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13B→partner) and Y-score (partner→VPS13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MCF2L →	+1.134	+3.201	<.001	.006	3	3
BLOOD_Lymphoma	CEACAM16 →	+0.025	+2.544	<.001	.007	3	3
LUNG_SCLC	NCR3 →	+0.121	+2.544	.007	.006	3	3
LARGE_INTESTINE	TTC5 →	+0.607	+2.652	<.001	.001	3	3
LARGE_INTESTINE	GDPGP1 →	+0.532	+1.969	<.001	<.001	3	3
LARGE_INTESTINE	RTCB →	+0.437	+2.546	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,023 associations by consensus.

MCF2L by VPS13B expression — BLOOD_Lymphoma

Explore this box plot interactively →