VPS13B-DT

Across TCGA pan-cancer cohorts, VPS13B-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VPS13B-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VPS13B-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS13B-DT expression acts as an unfavorable survival marker, although some lineages such as BLCA and READ show a favorable association.

KIRC, BLCA, and READ are the cancer types where VPS13B-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.432	0.614	.001	91	view →
BLCA	DFS	Quartile	IV	0.606	0.302	.002	57	view →
READ	OS	Tertile	II,III,IV	0.860	0.421	<.001	40	view →
ACC	OS	Median	All	0.412	0.932	<.001	39	view →
HNSC	DFS	Median	III,IV	0.493	0.684	<.001	30	view →
KICH	OS	Median	III,IV	0.556	1.000	.010	29	view →
COAD	OS	Median	III,IV	0.269	0.712	.002	27	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	21	view →
KIRP	DFS	Median	All	0.968	0.591	.001	18	view →
PRAD	DFS	Tertile	All	0.735	0.838	<.001	16	view →
PAAD	DFS	Median	III,IV	0.893	0.470	.024	9	view →
THCA	DFS	Quartile	All	0.982	0.919	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

VPS13B-DT–KIRC (DFS)

Open the KIRC breakdown →