VPS13B-DT

Across TCGA pan-cancer cohorts, VPS13B-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VPS13B-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VPS13B-DT RNA is repressed in tumor relative to normal tissue. In most cancer types VPS13B-DT is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where VPS13B-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS13B-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.239	<.001	11	view →
THCA	Male	III,IV	−1.027	<.001	11	view →
LIHC	Male	II,III,IV	+1.489	<.001	9	view →
KIRP	Male	III,IV	−1.271	<.001	9	view →
KICH	All	All	−1.120	<.001	7	view →
LUAD	Female	III,IV	−0.864	<.001	6	view →
UCEC	All	All	−0.734	.001	6	view →
BRCA	Female	II,III,IV	−0.639	<.001	6	view →
CHOL	All	All	+1.284	<.001	5	view →
LUAD	All	IV	+1.089	.017	2	view →
BLCA	All	IV	−0.887	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

VPS13B-DT–KIRC

Open the KIRC breakdown →