VPS13A-AS1

Across TCGA pan-cancer cohorts, VPS13A-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated VPS13A-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS13A-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS13A-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, KIRP, and THCA are the cancer types where VPS13A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.530	0.268	.008	81	view →
KIRP	OS	Median	III,IV	0.835	0.287	<.001	71	view →
THCA	OS	Tertile	III,IV	0.453	0.913	<.001	63	view →
CHOL	OS	Tertile	All	0.167	0.705	.021	36	view →
BLCA	DFS	Tertile	III,IV	0.116	0.340	.026	21	view →
COAD	OS	Tertile	III,IV	0.684	0.802	.025	15	view →
LGG	DFS	Tertile	All	0.600	0.756	.007	15	view →
THYM	OS	Tertile	All	0.731	0.940	.021	15	view →
UCEC	OS	Tertile	All	0.888	0.931	.035	12	view →
MESO	DFS	Tertile	IV	0.130	0.405	.019	9	view →
PAAD	DFS	Tertile	II,III,IV	0.302	0.503	.036	9	view →
READ	OS	Tertile	II,III,IV	0.757	0.937	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

VPS13A-AS1–HNSC (DFS)

Open the HNSC breakdown →