VPS13A-AS1

Across TCGA pan-cancer cohorts, VPS13A-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of VPS13A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VPS13A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types VPS13A-AS1 is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRC, and BRCA are the cancer types where VPS13A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS13A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.117	<.001	6	view →
KIRC	All	II,III,IV	+0.083	.015	5	view →
BRCA	All	All	+0.033	.018	4	view →
ESCA	All	II,III,IV	+0.155	.025	2	view →
KIRP	Male	All	−0.113	.031	2	view →
BLCA	Male	III,IV	+0.145	.048	1	view →
THCA	Female	All	−0.028	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

VPS13A-AS1–COAD

Open the COAD breakdown →