VPS11

Across TCGA patient cohorts, VPS11 protein abundance is significantly associated with the RNA expression of many other genes, with 15,414 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VPS11-associated genes across cancer lineages are IFFO1, ARHGAP20, and DPEP2. Each is linked with VPS11 in more than 5 cancer types. Because this analysis shows association rather than direction, both VPS11-to-partner and partner-to-VPS11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS11 versus IFFO1 in BRCA, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS11→partner) and Y-score (partner→VPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFFO1 →	+0.563	+0.164	<.001	<.001	3	6
UCEC	ARHGAP20 →	+0.962	+0.157	<.001	<.001	3	6
HNSC	DPEP2 →	+0.791	+0.152	<.001	.001	3	6
GBM	ITGAM →	+0.756	+0.111	.001	.003	3	6
LSCC	TLR7 →	+0.748	+0.175	<.001	<.001	3	6
GBM	CSF2RA →	+0.690	+0.095	.005	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,414 associations by consensus.

VPS11 vs IFFO1 — BRCA

Explore this scatter interactively →