VPS11

Across TCGA pan-cancer cohorts, VPS11 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of VPS11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VPS11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS11 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where VPS11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.759	<.001	11	view →
LIHC	Female	II,III,IV	+1.534	<.001	9	view →
KIRP	All	All	+0.310	.002	9	view →
COAD	All	All	+0.266	<.001	9	view →
LUSC	Female	All	−0.549	<.001	6	view →
KICH	Female	All	−0.576	<.001	5	view →
UCEC	All	All	−0.693	<.001	4	view →
HNSC	All	III,IV	+0.375	.024	4	view →
BRCA	All	II,III,IV	−0.324	<.001	4	view →
CHOL	All	All	+1.815	<.001	3	view →
ESCA	Female	All	+0.710	.005	1	view →
STAD	Male	II,III,IV	+0.579	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

VPS11–KIRC

Open the KIRC breakdown →