VPS11

Across TCGA patient cohorts, VPS11 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS11-associated genes across cancer lineages are eEF2, GAPDH, and Akt_pS473. Each is linked with VPS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS11-to-partner and partner-to-VPS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by VPS11-low versus VPS11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS11→partner) and Y-score (partner→VPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.366	+1.765	.006	.014	3	2
UCEC	GAPDH →	+0.628	+2.807	.001	.003	3	2
UCEC	Akt_pS473 →	+0.723	+2.000	.007	.030	3	2
UCEC	Akt_pT308 →	+0.718	+2.700	.002	.006	3	2
UCEC	Rad50 →	-0.181	-2.321	.047	.034	3	2
UCEC	ASNS →	+0.505	+2.169	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by VPS11 expression — UCEC

Explore this box plot interactively →