VPS11

Across TCGA cell cohorts, VPS11 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS11-associated genes across cancer lineages are SLC15A5, ITIH6, and PMP2. Each is linked with VPS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS11-to-partner and partner-to-VPS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC15A5 grouped by VPS11-low versus VPS11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS11→partner) and Y-score (partner→VPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC15A5 →	+0.023	+5.415	<.001	.004	3	1
BLOOD_Leukemia	ITIH6 →	+0.017	+3.754	<.001	.006	3	1
BLOOD_Leukemia	PMP2 →	+0.037	+3.847	<.001	.004	3	1
BLOOD_Leukemia	PLEKHS1 →	+0.104	+3.551	<.001	.008	3	1
BLOOD_Leukemia	LYZL2 →	+0.016	+4.569	<.001	.003	3	1
BLOOD_Leukemia	TLX3 →	+1.288	+4.266	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SLC15A5 by VPS11 expression — LARGE_INTESTINE

Explore this box plot interactively →