VPREB3

Across TCGA patient cohorts, VPREB3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPREB3-associated genes across cancer lineages are C7orf77, OR10A3, and SNORD114-23. Each is linked with VPREB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPREB3-to-partner and partner-to-VPREB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf77 grouped by VPREB3-low versus VPREB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPREB3→partner) and Y-score (partner→VPREB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C7orf77 →	+0.167	+3.719	<.001	.008	3	1
UCEC	OR10A3 →	+0.169	+4.184	<.001	.003	3	1
SKCM	SNORD114-23 →	+0.513	+7.816	<.001	.008	3	1
SKCM	MIR488 →	+0.623	+7.816	<.001	.008	3	1
SKCM	RNA5SP56 →	+0.352	+7.816	<.001	.008	3	1
SKCM	RNY4P29 →	+0.410	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

C7orf77 by VPREB3 expression — UCEC

Explore this box plot interactively →