VPREB1

Across TCGA patient cohorts, VPREB1 mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. COAD shows the largest number of these associations.

The most reproducible VPREB1-associated genes across cancer lineages are RNU6-739P, GH2, and RDXP1. Each is linked with VPREB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPREB1-to-partner and partner-to-VPREB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-739P grouped by VPREB1-low versus VPREB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPREB1→partner) and Y-score (partner→VPREB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-739P →	+0.136	+4.411	<.001	.005	3	2
COAD	GH2 →	+1.019	+4.790	<.001	.006	3	2
SKCM	RDXP1 →	+0.039	+2.728	<.001	.009	3	2
SKCM	MIR4452 →	+0.249	+4.411	<.001	.005	3	2
UCEC	DEFB104A →	+0.132	+5.151	<.001	.001	3	1
UCEC	DDX55P1 →	+0.160	+3.489	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

RNU6-739P by VPREB1 expression — SKCM

Explore this box plot interactively →