VNN3

Across TCGA patient cohorts, VNN3 mutation is significantly associated with the RNA expression of many other genes, with 3,844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VNN3-associated genes across cancer lineages are DAD1, CDT1, and ONECUT1. Each is linked with VNN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both VNN3-to-partner and partner-to-VNN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAD1 grouped by VNN3-low versus VNN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN3→partner) and Y-score (partner→VNN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAD1 →	+0.446	+2.475	<.001	<.001	3	3
UCEC	CDT1 →	+0.834	+2.147	<.001	<.001	3	3
UCEC	ONECUT1 →	+0.264	+1.746	<.001	.001	3	3
BLCA	CNN3P1 →	+0.046	+4.588	<.001	.008	3	2
BLCA	SIM1-AS1 →	+0.268	+4.788	<.001	.006	3	2
BLCA	DPY19L4P2 →	+0.069	+4.299	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,844 associations by consensus.

DAD1 by VNN3 expression — UCEC

Explore this box plot interactively →