VNN3

Across TCGA patient cohorts, VNN3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VNN3-associated genes across cancer lineages are p62 Lck ligand, ASNS, and PDK1_pS241. Each is linked with VNN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both VNN3-to-partner and partner-to-VNN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by VNN3-low versus VNN3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN3→partner) and Y-score (partner→VNN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p62 Lck ligand →	+0.451	+3.169	.031	.019	1	4
UCEC	ASNS →	+0.428	+1.584	<.001	.034	3	2
LUSC	PDK1_pS241 →	+0.179	+2.825	.012	.033	3	1
UCEC	eIF4G →	+0.259	+1.362	.018	.037	3	1
UCEC	A-Raf_pS299 →	-0.159	-3.087	<.001	<.001	3	1
UCEC	ERK2 →	+0.158	+1.874	.019	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

p62 Lck ligand by VNN3 expression — SKCM

Explore this box plot interactively →