VNN2

Across TCGA patient cohorts, VNN2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VNN2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and TFRC. Each is linked with VNN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VNN2-to-partner and partner-to-VNN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by VNN2-low versus VNN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN2→partner) and Y-score (partner→VNN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.242	-3.459	.006	.005	3	2
UCEC	eIF4E →	+0.176	+3.906	.018	<.001	3	2
UCEC	TFRC →	+0.500	+1.662	.007	.011	3	2
UCEC	A-Raf_pS299 →	-0.110	-2.115	.009	.017	3	1
UCEC	Heregulin →	-0.132	-2.571	.002	.010	3	1
UCEC	INPP4B →	-0.293	-2.115	.010	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by VNN2 expression — UCEC

Explore this box plot interactively →