VNN2

Across TCGA pan-cancer cohorts, VNN2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VNN2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VNN2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VNN2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where VNN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VNN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.430	<.001	12	view →
KICH	Female	II,III,IV	−1.642	<.001	10	view →
LUSC	Male	II,III,IV	−2.047	<.001	8	view →
LUAD	Male	II,III,IV	−1.156	<.001	8	view →
BLCA	Male	All	−1.018	.001	6	view →
COAD	Male	All	−0.873	.001	6	view →
LIHC	All	All	+0.746	.004	3	view →
PAAD	Female	All	−1.714	.001	2	view →
KIRP	All	All	+0.761	.005	2	view →
UCEC	All	All	−0.659	.007	2	view →
ESCA	Female	All	+1.766	.017	1	view →
CHOL	Female	All	+1.503	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VNN2–KIRC

Open the KIRC breakdown →