VNN1

Across TCGA pan-cancer cohorts, VNN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VNN1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VNN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VNN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where VNN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.457	0.261	.015	13	view →
LUAD	OS	Tertile	III,IV	0.716	1.000	.013	11	view →
GBM	OS	Tertile	All	0.728	0.879	.012	8	view →
HNSC	OS	Median	II,III,IV	0.945	0.990	.042	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VNN1–PDAC (OS)

Open the PDAC breakdown →