Across TCGA patient cohorts, VN1R4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible VN1R4-associated genes across cancer lineages are FASN, 4E-BP1_pS65, and Bim. Each is linked with VN1R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VN1R4-to-partner and partner-to-VN1R4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VN1R4→partner) and Y-score (partner→VN1R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FASN →	+0.446	+3.807	.041	<.001	3	2
SKCM	4E-BP1_pS65 →	+0.214	+1.749	.016	.049	3	2
SKCM	Bim →	-0.288	-2.000	.015	.031	3	2
SKCM	MAPK_pT202_Y204 →	+0.524	+2.700	.008	.006	3	1
SKCM	MEK1_p_S217_S221 →	+0.228	+3.012	.030	.018	3	1
SKCM	Syk →	-0.573	-3.153	.009	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

VN1R4 survival (RNA) · tumor vs normal (RNA) · all VN1R4 data types