VMP1

Across TCGA pan-cancer cohorts, VMP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VMP1 data layer compared with 31 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VMP1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated VMP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BRCA, and LUAD are the cancer types where VMP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.963	0.625	.017	26	view →
BRCA	OS	Median	All	0.115	0.578	.002	24	view →
LUAD	OS	Median	All	0.158	0.835	<.001	24	view →
HNSC	OS	Median	IV	0.245	0.708	.027	21	view →
BLCA	DFS	Median	III,IV	1.000	0.295	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VMP1–UCEC (DFS)

Open the UCEC breakdown →