VMP1

Across TCGA patient cohorts, VMP1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VMP1-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and A-Raf_pS299. Each is linked with VMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VMP1-to-partner and partner-to-VMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by VMP1-low versus VMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VMP1→partner) and Y-score (partner→VMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.580	+2.247	.007	.001	3	2
UCEC	14-3-3_beta →	-0.133	-3.780	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.125	-1.700	.004	.042	3	1
UCEC	ACC1 →	+0.274	+1.750	.040	.049	3	1
UCEC	Heregulin →	-0.139	-3.571	.002	.002	3	1
UCEC	HSP70 →	-0.307	-1.502	.037	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by VMP1 expression — UCEC

Explore this box plot interactively →