VMA21

Across TCGA patient cohorts, VMA21 mutation is significantly associated with the RNA expression of many other genes, with 3,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VMA21-associated genes across cancer lineages are BNIP3P41, RNA5SP415, and SRXN1. Each is linked with VMA21 in more than 1 cancer types. Because this analysis shows association rather than direction, both VMA21-to-partner and partner-to-VMA21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P41 grouped by VMA21-low versus VMA21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VMA21→partner) and Y-score (partner→VMA21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P41 →	+0.010	+4.086	<.001	.005	3	2
UCEC	RNA5SP415 →	+0.593	+2.582	<.001	<.001	3	2
UCEC	SRXN1 →	+0.721	+2.790	<.001	<.001	3	1
UCEC	LINC01607 →	-0.727	-3.885	<.001	<.001	3	1
UCEC	NUDT3 →	+0.301	+2.839	.004	.001	3	1
UCEC	POM121C →	+0.486	+3.931	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,189 associations by consensus.

BNIP3P41 by VMA21 expression — UCEC

Explore this box plot interactively →