VMA21

Across TCGA pan-cancer cohorts, VMA21 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of VMA21’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VMA21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VMA21 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where VMA21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VMA21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.477	<.001	12	view →
BLCA	Male	III,IV	+1.115	<.001	12	view →
COAD	Female	II,III,IV	+1.104	<.001	11	view →
KIRP	All	II,III,IV	+0.748	<.001	10	view →
LIHC	Male	II,III,IV	+1.159	<.001	9	view →
KIRC	All	All	+0.294	<.001	9	view →
STAD	All	II,III,IV	+1.069	<.001	7	view →
THCA	All	All	−0.289	<.001	7	view →
LUSC	Male	II,III,IV	+0.886	<.001	6	view →
CHOL	Male	All	+1.966	<.001	5	view →
READ	All	All	+1.143	<.001	5	view →
LUAD	Male	All	+0.546	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

VMA21–HNSC

Open the HNSC breakdown →