VMA21

Across TCGA cell cohorts, VMA21 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,114 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VMA21-associated GO terms across cancer lineages are Vacuolar proton-transporting V-type ATPase complex assembly, Proton-transporting V-type ATPase complex assembly, and Positive regulation of mitochondrial ATP synthesis coupled electron transport. Each is linked with VMA21 in more than 19 cancer types. Because this analysis shows association rather than direction, both VMA21-to-partner and partner-to-VMA21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuolar proton-transporting V-type ATPase complex assembly grouped by VMA21-low versus VMA21-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VMA21→partner) and Y-score (partner→VMA21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Vacuolar proton-transporting V-type ATPase complex assembly →	+0.305	+0.851	<.001	<.001	3	20
BREAST	Proton-transporting V-type ATPase complex assembly →	+0.191	+1.006	<.001	<.001	3	19
CNS	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.096	+0.482	.001	<.001	3	10
OVARY	scaRNA localization to Cajal body →	+0.105	+0.887	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of plasma cell differentiation →	-0.152	-1.112	<.001	.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of plasma cell differentiation →	-0.150	-1.139	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,114 associations by consensus.

Vacuolar proton-transporting V-type ATPase complex assembly by VMA21 expression — LIVER

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