VLDLR-AS1

Across TCGA pan-cancer cohorts, VLDLR-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VLDLR-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher VLDLR-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VLDLR-AS1 expression acts as an unfavorable survival marker, although some lineages such as THYM and PAAD show a favorable association.

UVM, BLCA, and ACC are the cancer types where VLDLR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.326	0.662	<.001	83	view →
BLCA	DFS	Median	All	0.258	0.432	.001	42	view →
ACC	DFS	Median	All	0.203	0.736	<.001	42	view →
LIHC	OS	Quartile	All	0.654	0.837	<.001	37	view →
THYM	DFS	Tertile	All	0.949	0.605	.001	34	view →
KIRP	OS	Quartile	All	0.803	0.941	.005	24	view →
LUAD	DFS	Quartile	II,III,IV	0.417	0.655	.013	22	view →
PAAD	DFS	Quartile	All	0.659	0.226	.002	21	view →
STAD	DFS	Tertile	All	0.477	0.617	.021	18	view →
MESO	OS	Quartile	All	0.553	0.312	.016	17	view →
OV	OS	Quartile	III,IV	0.869	0.773	.002	14	view →
DLBC	OS	Median	All	1.000	0.803	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VLDLR-AS1–UVM (DFS)

Open the UVM breakdown →