VLDLR-AS1

Across TCGA pan-cancer cohorts, VLDLR-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of VLDLR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where VLDLR-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types VLDLR-AS1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and STAD are the cancer types where VLDLR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VLDLR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.114	<.001	11	view →
COAD	All	II,III,IV	−0.314	<.001	10	view →
STAD	Female	All	−0.294	<.001	8	view →
BRCA	All	III,IV	−1.021	<.001	6	view →
BLCA	All	III,IV	−0.480	.009	5	view →
CHOL	All	All	+0.385	<.001	4	view →
KIRC	All	II,III,IV	−0.247	.004	4	view →
ESCA	Male	All	−0.234	.031	3	view →
LIHC	All	All	+0.117	.004	3	view →
READ	All	All	−0.641	<.001	2	view →
LUAD	All	II,III,IV	−0.186	<.001	2	view →
LUSC	All	III,IV	−0.258	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

VLDLR-AS1–THCA

Open the THCA breakdown →