VKORC1P1

Across TCGA pan-cancer cohorts, VKORC1P1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated VKORC1P1 data layer.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher VKORC1P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VKORC1P1 expression acts as an unfavorable survival marker, although some lineages such as CESC and MESO show a favorable association.

PAAD, THYM, and CHOL are the cancer types where VKORC1P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	II,III,IV	0.238	0.605	<.001	72	view →
THYM	OS	Tertile	III,IV	0.552	0.944	.002	54	view →
CHOL	DFS	Tertile	All	0.045	0.486	.009	45	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	42	view →
LUAD	DFS	Tertile	IV	0.421	0.734	.028	36	view →
CESC	DFS	Tertile	All	0.860	0.714	.032	30	view →
MESO	DFS	Tertile	All	0.394	0.167	.015	30	view →
BLCA	OS	Tertile	IV	0.209	0.479	.017	18	view →
LIHC	OS	Tertile	III,IV	0.059	0.738	<.001	18	view →
SKCM	OS	Tertile	All	0.435	0.280	.017	9	view →
THCA	OS	Tertile	III,IV	0.950	0.982	.018	9	view →
KIRC	DFS	Median	IV	0.312	0.559	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

VKORC1P1–PAAD (OS)

Open the PAAD breakdown →