VKORC1P1

Across TCGA pan-cancer cohorts, VKORC1P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of VKORC1P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VKORC1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VKORC1P1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, KICH, and BRCA are the cancer types where VKORC1P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VKORC1P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.030	.013	4	view →
KICH	All	All	−0.031	.017	2	view →
BRCA	All	III,IV	−0.028	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

VKORC1P1–HNSC

Open the HNSC breakdown →