VKORC1

Across TCGA patient cohorts, VKORC1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,091 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VKORC1-associated genes across cancer lineages are ARHGAP27, CHRNB2, and PLEKHJ1. Each is linked with VKORC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both VKORC1-to-partner and partner-to-VKORC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VKORC1 versus ARHGAP27 in HNSC, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VKORC1→partner) and Y-score (partner→VKORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP27 →	-0.583	-0.586	.001	.003	3	4
GBM	CHRNB2 →	-1.120	-0.466	<.001	<.001	3	4
UCEC	PLEKHJ1 →	-0.741	-0.691	.008	.007	3	3
HNSC	TMCO6 →	-0.838	-0.573	<.001	<.001	3	3
HNSC	NDUFA8 →	-1.272	-0.855	<.001	<.001	3	3
HNSC	TRIM25 →	-0.528	-0.497	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,091 associations by consensus.

VKORC1 vs ARHGAP27 — HNSC

Explore this scatter interactively →