VKORC1

Across TCGA patient cohorts, VKORC1 mutation is significantly associated with the RNA expression of many other genes, with 140 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VKORC1-associated genes across cancer lineages are RNU6-997P, RN7SL447P, and SRIP1. Each is linked with VKORC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VKORC1-to-partner and partner-to-VKORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-997P grouped by VKORC1-low versus VKORC1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VKORC1→partner) and Y-score (partner→VKORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-997P →	+0.262	+7.954	<.001	.008	3	2
COAD	RN7SL447P →	+0.391	+4.537	<.001	.006	3	2
SKCM	SRIP1 →	+0.131	+4.495	<.001	.007	3	2
UCEC	RNA5SP436 →	+0.277	+3.715	.002	.002	3	2
UCEC	GPATCH11 →	+0.574	+3.213	.005	.009	3	1
UCEC	OR2D2 →	+0.099	+3.633	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

RNU6-997P by VKORC1 expression — HNSC

Explore this box plot interactively →