VIRMA

Across TCGA patient cohorts, VIRMA mutation is significantly associated with the RNA expression of many other genes, with 3,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIRMA-associated genes across cancer lineages are MTHFD2, ERLIN1, and NCAPH. Each is linked with VIRMA in more than 4 cancer types. Because this analysis shows association rather than direction, both VIRMA-to-partner and partner-to-VIRMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2 grouped by VIRMA-low versus VIRMA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIRMA→partner) and Y-score (partner→VIRMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTHFD2 →	+0.820	+3.727	<.001	<.001	3	5
COAD	ERLIN1 →	+0.518	+3.489	<.001	.002	3	4
COAD	NCAPH →	+0.628	+3.700	<.001	.001	3	4
COAD	LDHA →	+0.486	+2.615	.002	.005	3	4
COAD	MRM3 →	+0.468	+2.598	.002	.006	3	4
COAD	NDC80 →	+0.736	+3.469	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,955 associations by consensus.

MTHFD2 by VIRMA expression — COAD

Explore this box plot interactively →