VIRMA

Across TCGA patient cohorts, VIRMA mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIRMA-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Cyclin-B1. Each is linked with VIRMA in more than 4 cancer types. Because this analysis shows association rather than direction, both VIRMA-to-partner and partner-to-VIRMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by VIRMA-low versus VIRMA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIRMA→partner) and Y-score (partner→VIRMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.366	+3.016	<.001	.018	3	5
UCEC	4E-BP1 →	+0.359	+2.906	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.698	+2.058	<.001	<.001	2	4
STAD	FASN →	+0.492	+2.823	.016	.034	3	2
UCEC	eIF4E →	+0.201	+3.820	.002	<.001	3	2
UCEC	JNK2 →	+0.153	+2.196	.015	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by VIRMA expression — COAD

Explore this box plot interactively →