VIP

Across TCGA pan-cancer cohorts, VIP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VIP data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VIP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated VIP expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

MESO, COAD, and CESC are the cancer types where VIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	II,III,IV	0.039	0.407	<.001	12	view →
COAD	OS	Median	All	0.172	0.870	<.001	12	view →
CESC	OS	Median	All	0.534	0.875	.048	6	view →
SKCM	DFS	Median	II,III,IV	0.831	0.559	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VIP–MESO (DFS)

Open the MESO breakdown →