VIP

Across TCGA pan-cancer cohorts, VIP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of VIP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VIP RNA is repressed in tumor relative to normal tissue. In most cancer types VIP is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and HNSC are the cancer types where VIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−3.628	<.001	11	view →
LUSC	Female	II,III,IV	−0.945	<.001	8	view →
HNSC	Male	All	−0.799	<.001	8	view →
LUAD	Female	All	−0.597	<.001	8	view →
KICH	All	All	−0.630	<.001	7	view →
STAD	All	All	−2.453	<.001	6	view →
UCEC	All	All	−1.062	<.001	6	view →
BRCA	Female	All	−0.713	<.001	6	view →
KIRP	Male	All	−0.515	<.001	6	view →
KIRC	All	All	+0.228	<.001	5	view →
BLCA	All	IV	−0.771	.021	4	view →
READ	Female	All	−4.744	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

VIP–COAD

Open the COAD breakdown →