VIP

Across TCGA patient cohorts, VIP mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIP-associated genes across cancer lineages are INPP4B, MEK1, and p27_pT198. Each is linked with VIP in more than 1 cancer types. Because this analysis shows association rather than direction, both VIP-to-partner and partner-to-VIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by VIP-low versus VIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIP→partner) and Y-score (partner→VIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.380	-3.321	.019	.010	3	1
UCEC	MEK1 →	+0.590	+3.459	.001	.005	3	1
UCEC	p27_pT198 →	+0.105	+3.000	.049	.036	3	1
UCEC	p38-MAPK →	-0.166	-2.979	.044	.036	3	1
UCEC	TFRC →	+0.689	+2.321	.009	.035	3	1
UCEC	Tuberin →	+0.382	+2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

INPP4B by VIP expression — UCEC

Explore this box plot interactively →